A vida de dois paramédicos de Nova Orleans é destruída depois que eles encontram uma série de mortes horríveis ligadas a uma droga projetada com efeitos bizarros e sobrenaturais.

Two young lovers, Maya and Jules, are found wrecked on the side of the road after a party by a loner roughneck, Freddy. During rehab, their relationship falls apart, and Maya forms an unlikely friendship with Freddy.

All hell breaks loose when a strange force animates the puppets up for auction at a convention, setting them on a bloody killing spree that's motivated by an evil as old as time.