Set during the true and unconscionable Central Intelligence Agency MK ULTRA drug experimentations in the early 1960s, MIDNIGHT CLIMAX follows the journey of Ford Strauss, a brilliant psychiatrist, whose moral and scientific boundaries are pushed to the limit as he is recruited to run a subsect of the program in a rural Mississippi Mental Hospital.

A married couple, trying to rebuild their relationship after an affair, travels to a secluded cabin and stumbles into a blood feud between the Native American owners of the property and the neighboring clan, who obsessively guard their land and punish those who trespass on it in terrifying ways.

Dois irmãos lutam com uma terrível verdade por trás de uma tragédia que visa separar três gerações de uma família.