It has been 2 years since the GCC raid in Anteiku. Although the environment in Tokyo has changed drastically due to the CCG's increased influence, Ghouls are still a problem, especially the Aogiri Tree organization.

After a crushing defeat at the Grand Prix Finals, Yuri contemplates retirement but catches the attention of five-time world champion Victor, changing the course of his future.

História da Guerra Santa, que ocorreu no século XVIII, 250 anos antes da série original de Saint Seiya. Se concentra na luta entre Tenma, um dos 88 santos que seguem Athena, e Alone, a reencarnação do deus Hades.