When Rodger Flank is invited to a college drinking game, things start to go terribly wrong. Told out of sequence, and from both sides of the fence, Manhunt is a story of revenge, psychosis, and childhood's end.

Hugh Laurie interpreta Dr. Gregory House, um médico mal-humorado que detesta lidar com pacientes, mas é um gênio no tratamento de doenças misteriosas.