Com base em acontecimentos verídicos, A Senhora de Guadalupe é uma descoberta religiosa comovente que justapõe o folclore com os tempos modernos.

A group of budding filmmakers are invited to a competition at the site of an unfinished 80's cult movie...and the death of its' infamous starlet. As the retreat progresses, something evil lurking behind-the-scenes begins to steal focus and the group become characters in a real-life horror film.