Komari lives in seclusion, tormented by her inability to drink blood despite being a vampire, her inability to use magic, her inability to exercise and her inability to grow.

The story takes place in year 1944 and the world lives in fear of unidentified flying objects called neuroi. A young heroine Named Yoshika miyafuji joins the 501st joint wing, known as the strike witches to fight and defeat the neuroi so that way she can protect the world.