Motoko Kusanagi e a Seção 9 encaram uma nova ameaça em 2045 neste filme que reconta a história da primeira temporada de Ghost in the Shell: SAC_2045.

Legendary half-vampire, half-human vampire hunter Blade is tracking Deacon Frost, a very powerful and influential vampire who killed his mother and who heads Existence, a secretive vampire organization that operates in Southeast Asia.