After being found not guilty for his crimes, Dr. Albert Beck takes a teaching job at a university, where his blossoming relationship with a student is threatened when one of his previous victims begins a campaign of terror against him.

During a robbery at a smart stop an EMT is faced with two victims; a pregnant lady and a man shot but still alive. When having to choose which to save first the injured man tells her take the pregnant lady, and she does. On her way back to get the man he is killed by the robber. Now the man's wife, Victoria, has been planning for ten years to exact revenge on her husband's death.

O policial John McClane não tem boa relação com seu filho. Os dois precisam deixar de lado suas diferenças para livrar o rapaz de uma acusação e proteger um terrorista que diz ter um dossiê contra um potencial candidato à presidência da Rússia.