Inspired by Sir Arthur Conan Doyle's classic literary characters, the series follows Dr. Wato-san Tachibana and Sara Shelly "Sherlock" Futaba, an eccentric police consultant who uses deduction to solve strange cases in modern-day Japan.

Ryu Sasakura (Masaki Aiba) is a bartending prodigy who won a European cocktail contest. He got into an argument with his instructor and was fired. In a state of dejection he came back to his native country of Japan. He finds work again in Tokyo and also meets Miwa Kurushima. Meanwhike, Ryu Sasakura is able to listen to his customer's problems and help alleviate their worries with his special cocktail mixes.